• Assist in the design, planning and implementation of clinical research projects
• Assist in the development of protocols, case report forms, informed consents, study manuals and study budgets
• Facilitate the negotiation of site contracts and budgets, manage and calculate site payments
• Perform site visits including site qualification, initiation, monitoring and close-out visits; co-monitor with regional monitors and review monitoring reports
• Ensure adherence to the protocol providing for accurate data collection, documenting drug accountability and compliance with federal regulations
• Represent Sangamo BioSciences in a professional manner; establish and maintain good relationships with investigators and study site personnel
• Maintain frequent site contact; prepare and track required documentation and manage study supplies at clinical sites
• Oversee and track project progress at assigned sites (patient status, safety/adverse events, CRF completion, payments, study drug supply, regulatory documents)
• Review data listings on an ongoing basis
• Assist in planning Investigator Meetings
• Assist in preparing interim study analyses, annual reports, and clinical study reports

Requirements:

• 2 to 3 years of Pharmaceutical industry experience including direct site management
• BA/BS degree in nursing, pharmacy, life sciences or health-related discipline
• Thorough knowledge of GCP, ICH and FDA regulations
• Strong organizational skills, detail oriented, and able to multi-task and work effectively in a fast-paced environment
• Self-motivated, assertive and able to function independently or as part of a team 
• Strong written and verbal communication; strong interpersonal skills
• Ability to travel 30-40%

• Assist in the design, planning and implementation of clinical research projects
• Manage the development of protocols, Investigator Brochures, case report forms, informed consents, study manuals and study budgets
• Negotiate and finalize site contracts and budgets, manage and calculate site payments
• Perform site visits including site qualification, initiation, monitoring and close-out visits; co-monitor with regional monitors and review monitoring reports
• Ensure adherence to the protocol providing for accurate data collection, documenting drug accountability and compliance with federal regulations
• Represent Sangamo BioSciences in a professional manner; establish and maintain good relationships with investigators and study site personnel
• Maintain frequent site contact; prepare and track required documentation and manage study supplies at clinical sites
• Oversee and track project progress at assigned sites (patient status, safety/adverse events, CRF completion, payments, study drug supply, regulatory documents).
• Review data listings on an ongoing basis
• Assist in planning Investigator Meetings
• Assist in preparing interim study analyses, annual reports, and clinical study reports
• Manage external vendors, develop study specifications, and finalize vendor contracts; vendors may include and are not limited to Contract Research Organizations (CROs), central laboratories, interactive voice response service for randomization (IVRS)

Requirements:

• 4 to 5 years of Pharmaceutical industry experience including direct site management
• BA/BS degree in nursing, pharmacy, life sciences or health-related discipline
• Thorough knowledge of GCP, ICH and FDA regulations
• Strong organizational skills, detail oriented, and able to multi-task and work effectively in a fast-paced environment
• Self-motivated, assertive and able to function independently or as part of a team 
• Strong written and verbal communication; strong interpersonal skills
• Ability to travel 30-40%

Sangamo has initiated multiple programs aimed at developing treatments for monogenic and infectious diseases using ZFNs to promote high efficiency genome editing (Urnov, et al., Nature, 435: 646). The initial therapeutic targets are diseases of the blood (Hemophilia, X-linked SCID, sickle cell anemia, and HIV/AIDS). This work is exciting, fast-paced, and may ultimately lead to effective treatments for these devastating diseases.

We are seeking a highly skilled and motivated Scientist I/II to join our therapeutic gene modification program.

The successful job candidate will be working in our Therapeutic Gene Modification group to aid in the research and pre-clinical development of this powerful new technology. Tasks would include the study and evaluation of our engineered ZFNs to promote high-efficiency gene modification in both model systems and in primary human cells. These studies would include analyzing the biological and physiological properties of permanently modified primary human cells (e.g. T-cells, hematopoietic stem cells, and hepatocytes) and characterizing the long-term therapeutic potential of this novel approach in model systems and in primary human cells. This person would also aid in the development of techniques and processes for the successful translation of this technology into the clinic, and would be assigned research projects to complete either independently or in collaboration with other team members.

Requirements:

We are seeking a Ph.D.-level scientist with extensive experience in cell culture as well as molecular biology techniques. The successful candidate should have hands-on expertise in the following laboratory techniques:

• Cloning
• DNA and RNA isolation
• Quantitative RT-PCR
• Southern blotting
• Generation and maintenance of tissue culture cell lines
• FACS analysis to examine reporter gene or cell-surface marker expression
• The culturing /manipulation of primary human cells
• Experience with the stimulation and expansion of primary CD4 or CD8 T lymphocytes
• Culturing hematopoietic stem cells and performing colony-forming assays (CFU-C and LTCIC assays)
• The generation and use of Adenoviral or Lentiviral vectors would be highly beneficial

Candidates must be highly motivated, have excellent communication skills, the capacity to analyze and interpret data without supervision, strong troubleshooting skills, and the ability to work well in a team environment.