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A particularly “elegant”(1) demonstration of the power and utility of ZFPs was published by scientists at Pfizer and Sangamo in the scientific journal genes and Development. In this paper scientists used ZFP TFs to determine the role of a specific splice variant of a gene involved in the process of adipogenesis, or fat cell development. ZFP TFs were generated that repressed the PPAR-gamma gene and we were able to clearly demonstrate that a particular variant, PPAR-gamma2, was required for adipocyte differentiation while PPAR-gamma1 was not. These data, which significantly advanced the field of adipogenesis, were facilitated by the equisite specificity and unique targeting properties of ZFP TFs. (1) See the PDF of commentary on this paper by Mitch Lazar Genes and Development 16: 1-5, 2002  PPAR-gamma
paper (596k PDF) Paper
Commentary (564k PDF) |
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Key
attributes of our ZFP TF technology that make it useful for the application
to animal research models are:
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