Sangamo's ZFP Technology Research and Review Articles
The following list of publications, authored by Sangamo scientists and others, contains original research articles and review articles that are relevant to our ZFP TF technology and its many applications.

Zinc Finger Protein Structure, Function and Rational Design

Pabo, C. O., Peisach, E., and Grant, R. A. (2001).Design and selection of novel Cys2His2 zinc finger proteins, Annu Rev Biochem 70, 313-40.

Isalan, M., Klug, A., and Choo, Y. (2001). A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter, Nat Biotechnol 19, 656-60.

Berg, J. M. (1997). Letting your fingers do the walking, Nat Biotechnol 15, 323.

Berg, J. M., and Shi, Y. (1996). The galvanization of biology: a growing appreciation for the roles of zinc, Science 271, 1081-5.

Jamieson, A. C., Wang, H., and Kim, S. H. (1996). A zinc finger directory for high-affinity DNA recognition, Proc Natl Acad Sci U S A 93, 12834-9.

Rebar, E. J., and Pabo, C. O. (1994). Zinc finger phage: affinity selection of fingers with new DNA -binding specificities, Science 263, 671-3.

Rhodes, D., and Klug, A. (1993). Zinc fingers, Sci Am 268, 56-9, 62-5.

Pavletich, N. P., and Pabo, C. O. (1991). Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A, Science 252, 809-17.


Gene Regulation with Zinc Finger Proteins

Jouvenot, Y., Ginjala, V., Zhang, L., Liu, P. Q., Oshimura, M., Feinberg, A. P., Wolffe, A. P., Ohlsson, R., and Gregory, P. D. (2003). Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors, gene Ther 10, 513-22.

Reynolds, L., Ullman, C., Moore, M., Isalan, M., West, M. J., Clapham, P., Klug, A., and Choo, Y. (2003). Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors, Proc Natl Acad Sci U S A 100, 1615-20.

Papworth, M., Moore, M., Isalan, M., Minczuk, M., Choo, Y., and Klug, A. (2003). Inhibition of herpes simplex virus 1 gene expression by designer zinc- finger transcription factors, Proc Natl Acad Sci U S A 100, 1621-6.

Ren, D., Collingwood, T. N., Rebar, E. J., Wolffe, A. P., and Camp, H. S. (2002). PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis , genes Dev 16, 27-32.

Rebar, E. J., Huang, Y., Hickey, R., Nath, A. K., Meoli, D., Nath, S., Chen, B., Xu, L., Liang, Y., Jamieson, A. C., et al. (2002). Induction of angiogenesis in a mouse model using engineered transcription factors, Nat Med 8, 1427-32.

Snowden, A. W., Gregory, P. D., Case, C. C., and Pabo, C. O. (2002). Gene-Specific Targeting of H3K9 Methylation Is Sufficient for Initiating Repression In Vivo, Curr Biol 12, 2159-66.

Liu, P. Q., Rebar, E. J., Zhang, L., Liu, Q., Jamieson, A. C., Liang, Y., Qi, H., Li, P. X., Chen, B., Mendel, M. C., et al. (2001). Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A, J Biol Chem 276, 11323-34.

Zhang, L., Spratt, S. K., Liu, Q., Johnstone, B., Qi, H., Raschke, E. E., Jamieson, A. C., Rebar, E. J., Wolffe, A. P., and Case, C. C. (2000). Synthetic zinc finger transcription factor action at an endogenous chromosomal site.Activation of the human erythropoietin gene, J Biol Chem 275, 33850-60.

Bartsevich, V. V., and Juliano, R. L. (2000). Regulation of the MDR1 gene by transcriptional repressors selected using peptide combinatorial libraries, Mol Pharmacol 58, 1-10.

Beerli, R. R., Dreier, B., and Barbas, C. F., 3rd (2000). Positive and negative regulation of endogenous genes by designed transcription factors, Proc Natl Acad Sci U S A 97, 1495-500.

Beerli, R. R., Segal, D. J., Dreier, B., and Barbas, C. F., 3rd (1998). Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks, Proc Natl Acad Sci U S A 95, 14628-33.

Kim, J. S., and Pabo, C. O. (1998). Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants, Proc Natl Acad Sci U S A 95, 2812-7.

Liu, Q., Segal, D. J., Ghiara, J. B., and Barbas, C. F., 3rd (1997). Design of polydactyl zinc-finger proteins for unique addressing within complex genomes, Proc Natl Acad Sci U S A 94, 5525-30.

Kim, J. S., and Pabo, C. O. (1997). Transcriptional repression by zinc finger peptides. Exploring the potential for applications in gene therapy, J Biol Chem 272, 29795-800.

Kim, J. S., Kim, J., Cepek, K. L., Sharp, P. A., and Pabo, C. O. (1997). Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression, Proc Natl Acad Sci U S A 94, 3616-20.

Choo, Y., Castellanos, A., Garcia-Hernandez, B., Sanchez-Garcia, I., and Klug, A. (1997). Promoter-specific activation of gene expression directed by bacteriophage-selected zinc fingers, J Mol Biol 273, 525-32.


Other Articles by Sangamo Scientists

Liang, Y., Li, X. Y., Rebar, E. J., Li, P., Zhou, Y., Chen, B., Wolffe, A. P., and Case, C. C. (2002). Activation of vascular endothelial growth factor A transcription in tumorigenic glioblastoma cell lines by an enhancer with cell type-specific DNAse I accessibility, J Biol Chem 277, 20087-94.

Urnov, F. D. (2002a). A feel for the template: zinc finger protein transcription factors and chromatin, Biochem Cell Biol 80, 321-33.

Urnov, F. D., Rebar, E. J., Reik, A., and Pandolfi, P. P. (2002). Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo: Fourth in review series on chromatin dynamics, EMBO Rep 3, 610-5.

Reik, A., Gregory, P. D., and Urnov, F. D. (2002). Biotechnologies and therapeutics: chromatin as a target, Curr Opin genet Dev 12, 233-42.

Li, G., Hall, T. C., and Holmes-Davis, R. (2002). Plant chromatin: development and gene control, Bioessays 24, 234-43.

Urnov, F. D. (2002b). Methylation and the genome: the power of a small amendment, J Nutr 132, 2450S-6S.

Urnov, F., and Crane-Robinson, C. (2002). Chromatin. The living genome, Eur J Biochem 269, 2267.

Schaal, T. D., Holmes, M. C., Rebar, E. J., and Case, C. C. (2002). Novel approaches to controlling transcription, Genet Eng 24, 137-78.

Wolfe, S. A., Grant, R. A., Elrod-Erickson, M., and Pabo, C. O. (2001). Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes, Structure (Camb) 9, 717-23.

Gregory, P. D. (2001). Transcription and chromatin converge: lessons from yeast genetics, Curr Opin Genet Dev 11, 142-7.

Wolffe, A. P. (2001a). Chromatin remodeling: why it is important in cancer, Oncogene 20, 2988-90.

Wolffe, A. P. (2001b). Transcriptional regulation in the context of chromatin structure, Essays Biochem 37, 45-57.

Urnov, F. D., and Wolffe, A. P. (2001a). Above and within the genome: epigenetics past and present, J Mammary Gland Biol Neoplasia 6, 153-67.

Urnov, F. D., and Wolffe, A. P. (2001b). Chromatin remodeling and transcriptional activation: the cast (in order of appearance), Oncogene 20, 2991-3006.

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