ASGCT 2025

Epigenetic Regulation for the Central Nervous System

ASGCT 2025

Presidential Symposium Presentation: Sustained Brain-wide Reduction of Prion via Zinc Finger Repressors in Mice and Nonhuman Primates as a Potential One-Time Treatment for Prion Disease

Abstract No. 2

Oral Presentation – May 14; 11:30-11:45 am CT
ASGCT 2025

Presentation: Preclinical Development of an AAV-delivered Zinc Finger Transcriptional Repressor Targeting the Prion Gene as a Novel Epigenetic Gene Therapy for Prion Disease

Abstract No. 389

Oral Presentation – May 17; 8:45-9:00 am CT
ASGCT 2025

Presentation: AAV-Mediated Delivery of an Engineered Zinc Finger Lead to Selective and Potent Repression of Nav1.7 in Human Sensory Neurons and Nonhuman Primates DRG Nociceptors Following Intrathecal Injection

Abstract No. 369

Oral Presentation – May 17; 8:45-9:00 am CT

Viral Engineering for the Central Nervous System

ASGCT 2025

Poster: Fitness Maturation of STAC-BBB Yields Second-Generation Capsid Variants with Enhanced Delivery to the Central Nervous System

Abstract No. 1909
ASGCT 2025

Poster: Characterization of Receptor-Targeted Blood-Brain Barrier Penetrant AAV Capsids

Abstract No. 1896
ASGCT 2025

Poster: Recombinant Adeno-Associated Virus (rAAV) Production in Spodoptera Frugiperda (Sf9) Cells: Viral Cathepsin Mediated Capsid Cleavage and Mitigation Strategies

Abstract No. 987
ASGCT 2025

Poster: Assessment of Adeno-Associated Virus (AAV) Purity by Capillary Electrophoresis-Based Western

Abstract No. 1814
ASGCT 2025

Poster: The Impact of Empty Capsids on AAV Manufacturing and Strategies for Enhancing Yield, Purity, and Stability in the Production of a Novel Blood-Brain Barrier Penetrant AAV Capsid

Abstract No. 1464

Next-Generation Genome Engineering

ASGCT 2025

Poster: A Protein-Guided Modular Integrase (MINT) Platform Enables Compact Therapeutic Payloads and Efficient Targeted Integration in T Cells

Abstract No. 648